Structural insights into humanization of anti-tissue factor antibody 10H10
نویسندگان
چکیده
منابع مشابه
Structural insights into humanization of anti-tissue factor antibody 10H10
Murine antibody 10H10 raised against human tissue factor is unique in that it blocks the signaling pathway, and thus inhibits angiogenesis and tumor growth without interfering with coagulation. As a potential therapeutic, the antibody was humanized in a two-step procedure. Antigen-binding loops were grafted onto selected human frameworks and the resulting chimeric antibody was subjected to affi...
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ژورنال
عنوان ژورنال: mAbs
سال: 2018
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2017.1412026